Said M Sebti Selected Research

Farnesyltranstransferase (Farnesyltransferase)

10/2019	Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.
12/2012	Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
11/2009	Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies.
7/2006	Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide.
9/2005	Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.
2/2004	Farnesyltransferase inhibitors.
9/2003	Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf.
1/2003	Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.
7/2002	Suppression of rho B expression in invasive carcinoma from head and neck cancer patients.
3/2002	RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.

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Said M Sebti Research Topics

Disease

42	Neoplasms (Cancer) 01/2020 - 03/2002
9	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019 - 11/2009
4	Breast Neoplasms (Breast Cancer) 01/2015 - 07/2006
4	Melanoma (Melanoma, Malignant) 12/2012 - 11/2009
2	Lung Neoplasms (Lung Cancer) 01/2020 - 09/2003
2	Carcinogenesis 10/2019 - 11/2018
2	Adenocarcinoma 05/2017 - 12/2013
2	Neoplasm Metastasis (Metastasis) 05/2017 - 12/2013
2	Brain Neoplasms (Brain Tumor) 12/2012 - 09/2005
2	Exanthema (Rash) 11/2009 - 01/2008
2	Pathologic Complete Response 04/2009 - 07/2006
1	Multiple Myeloma 03/2022
1	Graft vs Host Disease (Graft-Versus-Host Disease) 11/2017
1	Prostatic Neoplasms (Prostate Cancer) 01/2017
1	Ataxia Telangiectasia (Louis Bar Syndrome) 11/2014
1	Retinoblastoma (Glioblastoma, Retinal) 12/2013
1	Body Weight (Weight, Body) 10/2013
1	Carcinoma in Situ 04/2013
1	Hepatocellular Carcinoma (Hepatoma) 06/2011
1	Leukemia 09/2010
1	Adrenal Cortex Neoplasms (Adrenocortical Cancer) 11/2009
1	Papillary Thyroid Cancer 11/2009
1	Parasitic Diseases (Parasitic Disease) 02/2009
1	Falciparum Malaria (Plasmodium falciparum Malaria) 02/2009
1	Nausea 01/2008
1	Diarrhea 01/2008
1	Ataxia (Dyssynergia) 01/2008
1	Fatigue 01/2008
1	Fever (Fevers) 01/2008

Drug/Important Bio-Agent (IBA)

10	Farnesyltranstransferase (Farnesyltransferase)IBA 10/2019 - 03/2002
8	Phosphotransferases (Kinase)IBA 03/2022 - 07/2004
8	Proteins (Proteins, Gene)FDA Link 05/2013 - 03/2002
7	Vitamin E FDA LinkGeneric 01/2019 - 02/2006
6	TocotrienolsIBA 01/2019 - 12/2011
6	Biomarkers (Surrogate Marker)IBA 05/2017 - 02/2006
6	tipifarnib (R115777)IBA 12/2012 - 09/2005
5	Gemcitabine FDA Link 05/2017 - 12/2011
5	Pharmaceutical PreparationsIBA 10/2013 - 12/2007
3	TransferasesIBA 10/2019 - 04/2009
3	SurvivinIBA 12/2011 - 01/2004
2	DNA (Deoxyribonucleic Acid)IBA 03/2022 - 08/2014
2	Small Interfering RNA (siRNA)IBA 01/2020 - 05/2008
2	Therapeutic UsesIBA 01/2019 - 09/2012
2	CarcinogensIBA 11/2018 - 09/2003
2	Biological ProductsIBA 10/2014 - 04/2009
2	RRD 251IBA 12/2013 - 05/2008
2	4- (methylthio)- 7- (5- O- phosphonoribofuranosyl)- 7H- pyrrolo(2,3- d)pyrimidineIBA 05/2013 - 09/2012
2	Protein Tyrosine PhosphatasesIBA 07/2012 - 09/2010
2	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2009 - 07/2006
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 04/2009 - 07/2006
2	EnzymesIBA 09/2005 - 03/2002
2	ras ProteinsIBA 02/2004 - 03/2002
2	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 07/2002 - 04/2002
1	prexasertibIBA 03/2022
1	AntioxidantsIBA 01/2020
1	GTP Phosphohydrolases (GTPases)IBA 01/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020
1	Antineoplastic Agents (Antineoplastics)IBA 10/2019
1	LigandsIBA 01/2019
1	annattoIBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	Tocopherols (Tocopherol)IBA 01/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019
1	Death Domain ReceptorsIBA 01/2019
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 01/2017
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2017
1	TensinsIBA 01/2017
1	Caspase 3 (Caspase-3)IBA 01/2015
1	PeptidomimeticsIBA 10/2014
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 10/2014
1	imidazopyridineIBA 10/2014
1	Histones (Histone)IBA 05/2014
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 12/2013
1	raf KinasesIBA 12/2013
1	Growth Factor ReceptorsIBA 05/2013
1	MicronutrientsIBA 04/2013
1	Focal Adhesion Protein-Tyrosine KinasesIBA 09/2012
1	Insulin-Like Growth Factor I (IGF-1)IBA 09/2012
1	Somatomedin Receptors (Somatomedin Receptor)IBA 09/2012
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 08/2012
1	Interferon alpha-2 (Roferon-A)FDA Link 07/2012
1	Transcription Factors (Transcription Factor)IBA 12/2011
1	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA 06/2011
1	AZD 6244IBA 06/2011
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2010
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 11/2009
1	Sorafenib (BAY 43-9006)FDA Link 11/2009
1	Filgrastim (Neupogen)FDA Link 04/2009
1	Cytotoxins (Cytolysins)IBA 04/2009
1	Molecular Probes (Molecular Probe)IBA 02/2009
1	BilirubinIBA 01/2008
1	Transaminases (Aminotransferases)IBA 01/2008

Therapy/Procedure

11	Therapeutics 10/2019 - 04/2007
5	Drug Therapy (Chemotherapy) 05/2017 - 04/2009
3	Chemoprevention 05/2017 - 09/2003
2	Immunotherapy 12/2012 - 10/2005
1	Precision Medicine 11/2018
1	Cell Transplantation 11/2017
1	Radiotherapy 09/2012
1	Intraperitoneal Injections 09/2012